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Two lifelong friends, who are both architects, form a business partnership. Partners is a comedy that is about a life long bromance between Joe and Louis, two architects who have been friends nearly their entire lives. They are now are business partners, owning their own small architecture firm. Joe is very rational and level headed, following his head over his heart, sometimes a detriment to his relationships. Joe is newly engaged to Ali, a beautiful jewelry designer who brings out the best in him. Louis, in contrast to Joe, is passionate, outspoken and tends to exaggerate in order to make his point. Louis' partner's name is Wyatt, and is a vegan male nurse who is soft spoken and overly understanding. As they live their lives they must find a way to adapt, redefining the bond between them both personally and professionally now that there is an addition of two other important relationships.
When Joe must decide whether or not to ask Ali to marry him, Louis and his good intentions threaten to get in the way of his best friend’s happiness.
Joe and Louis bicker about who takes better care of whom when Louis discovers that Joe and Ali haven’t been “romantic” lately.
After Joe uncovers sexy photos of Ali with famous baseball player Derek Jeter and tells Louis about it, Ali questions Joe’s ability to keep a secret from his partner.
Joe is stuck in the middle after Ali finds out that Louis has a key to Joe’s apartment and she does not.
Joe and Louis’ financial problems force the partners to ask for their old jobs back. Meanwhile, Joe questions just how platonic Ali’s overly friendly kiss with Wyatt really is.
Louis insists on hiring Wyatt as their personal assistant, much to Joe's resistance. In the end, things do not work out the way Louis intended. In the Meantime, Ali tries to find a caterer for a party at her shop.
Joe is torn as to where he and Ali should socialize when he realizes that he doesn’t fit in with her friends and she doesn’t fit in with Louis’s.
After Louis offers Joe his grandmother's ring to give to Ali as her long-awaited engagement ring, he is shocked when a hurt Wyatt objects.
Joe and Louis are hired to plan a house for a big shot British client, nonetheless, friction develops between the two partners as Louis takes full credit for one of the design's concept.
Joe tries to hide his new straight friend Russ from Louis.
Joe and Louis are nominated for an "Archie" award, however, the begin to doubt the originality of their submitted design.
Joe and Louis argue about which one is the better looking of the pair. Meanwhile, Ali films a commercial for her store that will air in taxis and Wyatt has a problem with his new driver's license.
Ali gets a pregnancy scare, Louis decides to have a baby as well, Joe and Louis' relationship is tested.
