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The daily adventures of a 12 year old Mexican superhero dealing with bizarre enemies, as well as his own superhero father and villain grandfather.
While "borrowing" Rodolfo's supercharged Bronze Boots of Truth, Manny and Frida break them. Manny covers it up until Rodolfo slips into a depression after being beaten by El Oso.
Manny spends money on a laser tattoo maker instead of some expensive guacamole, so Manny gets some for free from a disguised Dr. Chipotle Jr. which turns Rodolfo and Grandpapi into guacamole zombies.
Manny spends his time with a new supervillainess named Black Cuervo, nearly ruining his friendship with Frida (and her fiesta) in the process.
While making some roller skates, Manny and Frida earn money for finding the town's lost pets so they can buy Luxe roller skates and scooters then earn a bigger cash reward if they return a Chihuahua named Taco to his rightful owner.
Grandpapi decides to coach Manny's soccer team, with disastrous results.
Manny helps his friends and classmates at Escuela get better grades. but when he gets carried away, Frida and classmates unknowingly consult a supervillain to go against him.
Manny cares for the town's mascot Zebra Donkey but after accidentally killing him, Manny and Frida use Sartana of the Dead's Golden Guitar of Doom to resurrect him, unaware of the grave consequences.
During a dangerous day at a carnival, Manny encounters the Titanium Titan, a former superhero with shapeshifting titanium arms. To keep Frida out of harm's way from the Titan, Manny must end his friendship with Frida.
When Manny's mother, Maria, comes to visit, Manny and friends are afraid he'll be forced to live with her due to Miracle City's bad status. They then decided to show her that Miracle City isn't all that bad.
Manny and Frida help a group of retired supervillains get their money back from Sartana of the Dead. But just because they're retired, doesn't mean they are no longer supervillains.
Manny and Frida must be at the Escuela in time or they will be forced to go to separate schools.
Manny and Frida accidentally ruin a group of geeky kids' game night but when The Mustache Mafia attack, they must work together to defeat them.
Manny is tired of being a kid so he enlists the help of Dr. Chipotle Jr. to give him a sentient mustache named Raul in exchange for his El Tigre belt.
When Manny overhears Rodolfo and Maria voice their concern over Grandpapi being a bad influence on him, Manny and Frida uses his suit to do heroic things to prove he isn't a bad influence. But Grandpapi might not be ok with this.
Maria tries to reform supervillains into becoming good citizens but Manny isn't convinced they can change.
Manny is rejected as a hero by other superheroes while attending a superhero convention. But when Sartana Of The Dead and other supervillains run amok and trap the heroes at the convention, it is up to Manny to prove them wrong and save the day.
Upon learning Rodolfo retreated from a fight with El Mal Verde, Manny is disappointed his father acted cowardly and tries to face El Mal Verde himself.
When The Seventh Samurai visits the Rivera household, Manny and Frida take his son, Toshiro, around Miracle City for him to become a real independent superhero.
When an aspiring superhero kid named Davi asks Manny to help him become a hero, Manny and Frida trick him into doing their chores. But when Manny and his family are in danger, it's up to Davi to be a hero and save them.
Tired of being powerless, Frida "borrows" Manny's belt and becomes the superheroine "La Tigresa."
