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Four friends meet two aliens and are given special devices called Battleballs which give each of them superpowers and must stop an alien virus from infecting every living creature on the planet.
Mem and Zen realize their mistake in picking the Noobs and want to take the battleballs back. In order to save themselves the Noobs must go to space to plead their case to the Benevolent Alliance and keep their battleballs. There they are tested individually and judged on their abilities to fight the virus.
The Noobs make the Cornbury News after fighting a virus beast in the park and realize that they will need superhero costumes to hide their identity. Mem and Zen go to work finding the perfect Earth hero costumes.
The Noobs discover that Mem and Zen have the power to transform themselves into people and imitate their voices. Tyler goes on a date with Amy Anderson to the new smoothie shop when an active yogurt culture smoothie becomes infected with the virus.
Nervous that the virus could attack at any minute Kevin insists on wearing his battleball in school when it malfunctions and he gets stuck as a dog. Upon getting caught by the dog catcher and thrown in the pound the virus begins to infect the stray animals. The Noobs must find a way to free him from the pound before he is stuck that way forever while battling the Virus.
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A new strain, called the elimination virus is discovered that has the ability to infect a human without changing their appearance. In an attempt to destroy the Noobs, the virus infects the glee club and they must battle them in a sing and dance off in front of the whole school.
The Noobs training continues as they learn new ways to use their powers to defeat the virus. Realizing that they could use their powers to also defeat their schools arch rivals, the Eastside Wolves, the Noobs join the football team and are faced with a moral dilemma of getting caught.
Shope's parents are concerned about her performance in school and feel that the boys are bad influence. The Noobs sneak into the Galacticus cloaking room where the energy is transferred to Shope, making her invisible instead of the Galacticus. The boys have to keep Shope out of trouble until Mem and Zen can make her visible again.
The Noobs turn to Mem and Zen to help them prepare for the upcoming school dance where a fire virus turns students into fire breathing dragons. In an effort to get closer to Amy, Tyler's plan to save her in his Supernoobs costume backfires when she falls for the super hero version of himself instead.
During rehearsal for the school play where Roach plays a rocket, his battleball becomes activated by his love for the drama coach making him shoot off like a real rocket. Fearful that he will be mistaken for a real missile and shot down the Noobs must find a way to rescue him and bring him back down to Earth.
When Tyler and Shope's guinea pig escapes from home ec class Kevin has to become a guinea pig to sit in while Tyler searches for the real one. Tyler and Roach then discover a virus that recently landed only to find the guinea pig has eaten several of them. Now they must conquer the virus beats and get the guinea pig back in its cage before the end of class.
Mem and Zen take the Noobs to space for the New Virus Warrior Convention and Recruiters Awards where they are not taken seriously and spend the time in their hotel room instead. Meanwhile at the Awards Ceremony, Count Venamus is set on spreading the virus to all the new recruits leaving only the Noobs uninfected to battle the virus.
The Benevolent Alliance has come to inspect the Noobs battleballs, the only problem is they have misplaced them. Mem and Zen fake a virus attack to stall while the Noobs retrace their steps in order to find the battleballs before the leaders discover that they have lost them.
While on a field trip to the museum, the Tyrannosaurus skeleton gets infected by the virus and comes to life.
Roach's battleball malfunctions, transforming him into an evil super villain bent on dominating the Earth
Mem and Zen decide to become directors and create a TV show based on their adventures with the Noobs
The Noobs pilot the Galacticus into space to get medicine for Mem and Zen's infected eyes, and end up helping a space princess overthrow an evil dictator.
When Count Venamus returns with a giant robot, and a plan to use a virus pod meteor shower to infect the planet, the Noobs turn the Galacticus into a giant robot to stop him.
The Noobs travel to an alien zoo with Mem and Zen, only to be captured and put into a exhibit by the zoo's owner.
