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Christina and Tom's wedding doesn't go as planned, Nick investigates the cause of an attack at the hospital. Candy finally goes into labor after almost losing her life.
Tom and Christina deal with the explosion at the hospital and her pregnancy differently. Camille may have found a new love interest. Bobby and Christina argue over hospital duties. Also a little girl is left at the front of the hospital for no apparent reason.
Nick asks Christina for help with his mom who is ill, Dr. Steve shaw gets a surprise visit from his father. An internal affairs investigator comes to James river looking into the events surrounding the attack that recently took place. Tom is becoming concerned with Camille's interest in the new doctor at the hospital practicing under Tom.
Jimmy Dupree is still questioning the nursing staff of James River about the events that led up to the attack and nick is questioned about the attack that night. James River holds a health affair that leads Kelly to get in an argument with bobby over how to continue after a capital MERSA outbreak is suspected. Morrissey begins to fall apart because of stress due to recent events taking place at the hospital.
Christina and Tom spend the day with Miles’ kids who are in town visiting. Bobbie is photographed for an article about James River. Kelly and Dr. Marshall learn more about each other. And investigator Jimmy Dupree returns to question Detective Renata.
Christina and Nick through his mom a party. Camille discovers something about Miles that could change their relationship drastically. Bobby holds a fundraiser for the James River cancer and research lab; also problems become a problem for the CEO of James River Hospital
Christina is given an opportunity after losing her job at the hospital. Camille and Miles have to make a decision about their relationship after learning something about Miles. Bobbie makes a mistake that could cost her the job that Christina once held. Tom's dislike of Nick only increases.
When Christina’s life becomes too much to handle alone, she seeks refuge in therapy, where she opens up about her husband, Det. Nick Renata, marriage, her daughter and even her own childhood. Meanwhile, Tom faces the daunting task of keeping a friend’s spirits hopeful while confirming a difficult diagnosis.
Camille Hawthorne tries offering advice and comfort to her mother, Christina, whose choices will have dramatic consequences on the lives of Tom and Det. Nick Renata. Meanwhile, Miles prepares to say goodbye to James River. Chi McBride also guest-stars.
Christina returns to James River; Tom must perform surgery on a friend; Kelly has a career-changing moment; Bobbie and Steve consider a move; Camille contemplates leaving for college.
